Nanosyn personnel work with a scale-up mentality and listen closely to insure matching up our response to best fit a client’s needs. Our chemists are capable of designing a process from scratch, developing and optimizing a discovery process to prepare for scale-up on site or at a larger scale elsewhere, or providing rapid turnaround of a product by an existing process.
Typical Project Flow:
R&D Services include:
cGMP Services include:
Analytical Services include:
Regulatory Services include:
At our kilolab scale in Santa Rosa, we can handle most chemistries safely and efficiently. Some of our recent chemistry challenges have involved working with lithium aluminum and sodium hydrides, hydrogen sulfide, and performing Suzuki couplings, Mitsunobu reactions, hydrogenations, specialty polymerizations, and diafiltrations.
Nanosyn’s chemists stress the replacement of process steps involving expensive and time consuming chromatographies, but have extensive experience with operating chromatographic techniques when necessary. Specialty equipment beyond traditional gravity flow glass columns includes Biotage Flash 150, Biotage Kiloprep, and an Isco all plastic system.
Nanosyn’s internal operating procedures stress the development and operation of safe processes. Some of our recent handling challenges have included working with air, moisture, and light sensitive compounds. The handling of highly toxic compounds is evaluated on a case by case basis. If necessary for toxic compounds, we can work in a disposable glove bag in a fume hood with personnel in full body suits with self contained air supply. For safety reasons, and at the request of clients we do not bring on site compounds with known potential acute hazards at very low levels such as penicillins and steroids.
The site is registered with the DEA for Schedule II, III, and IV controlled substances.
Product and Equipment storage services:
Specialty equipment includes:
In addition to the specialty chromatography equipment listed above, the site has the capability for large scale rotary evaporation and a wiped film evaporator, and is continually adding more equipment as needed to increase site capabilities.