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Nanoscale Combinatorial Synthesis Announces Combinatorial Chemistry Deal With Caliper Technologies Corp.

TUCSON, Ariz., Feb. 8 /PRNewswire/

Nanoscale Combinatorial Synthesis Inc. (Nanosyn) today announced that it will provide Caliper Technology Corp. with custom combinatorial libraries designed to combine Caliper's microfluidics screening technology with Nanosyn's expertise in miniaturized synthesis and distribution of compound libraries.

"We provide a cost-efficient solution for the generation of large and diverse libraries as well as for synthesis of focused libraries using proprietary buildingn blocks,'' notes Dr. Nikolai Sepetov, President and CEO of Nanosyn. "The scale of synthesis should ideally match the submicrogram quantities of material used in modern screening assays in order to eliminate the waste and long term storage of expensive compound collections. Just as important, small scale synthesis of combinatorial libraries allows the incorporation of unusual building blocks which are normally eliminated from consideration due to expense or availability.''

Dr. C. Nicholas Hodge, Director of Drug Discovery Technologies at Caliper, commented, "We believe that matching the scale of synthesis with the small amounts of material required for modern high throughput screening creates unique opportunities for both lead discovery and lead optimization. Caliper Technologies is a leader in this area and a natural partner for Nanosyn.''

Based in Tucson, Arizona, Nanosyn was established by a group of scientists with extensive expertise in combinatorial organic synthesis, analysis of combinatorial libraries, and high throughput screening. The company provides access to a large collection of analytically characterized compounds preformatted for high-density screening, and has developed a proprietary miniaturization platform, Accelerated Nanoscale Synthesis Technology (ANSTTM). ANSTTM streamlines the interface between the synthesis of diverse collections of organic compounds with "drug-like'' characteristics and high throughput screening assays, dramatically reducing both the time and expense of modern lead discovery programs. More information about Nanosyn's products and services can be found on the World Wide Web at

Caliper Technologies designs and manufactures LabChipTM devices and LabChipTM device-based systems that enable high-throughput experimentation and information access for faster drug discovery, improved medical treatment, and more accurate and cost-effective biological and genetic research. Caliper's microfluidic LabChipTM devices process fluid like semiconductors process electrons, executing biological tests in seconds. Experimental data, in digital form, can be stored in databases, accessed via networks and shared by researchers. With its ability to accelerate experimentation and expand access to information, Caliper's LabChipTM technology is dramatically changing the fundamental processes of research, discovery and diagnosis. Since its incorporation in 1995, Caliper has forged major strategic partnerships and expanded its intellectual property portfolio to become a leader in Lab-on-a-Chip technology. Caliper is commercializing its proprietary LabChipTM products through strategic relationships that include Hewlett-Packard, Hoffmann-La Roche, Amgen and Dow Chemical. More information about Caliper can be found at

(Nanoscale Combinatorial Synthesis Inc.)
625 Clyde Ave., Mountain View, CA 94043-2213 USA
Phone: 650-404-8050 Fax: 650-428-1770

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